The objective of this study was to evaluate the application of the use
optimization methods of Simplex Lattice Design (SLD) with special cubic models in the
preparation formula of hard capsule based on goatskin gelatin. Three types of filler
materials have been used in the manufacture of capsule shells, namely MgCO3, tapioca
starch (TS) and sago starch (SS). The basic ingredient was uses goatskin gelatin and
aquadest as a solvent. The material formulation was calculated according to Simplex
Lattice Design (SLD) using the equations Y = β1 (A) + β2 (B) + β3(C) + β12 (A)(B) +
β13 (A)(C) + β23 (B)(C) + β123 (A)(B) (C). Based on these equations obtained seven
formulas (three proportions formula 100% each component, three proportional formulas
50%: 50% for the mixture of two components and one formula 33.33% for the mixture
of three components). The results obtained data related to the proportion of filler use in
a mixture of materials. The superimposed contour plot shows that the proportion of the
use of three types of filler (MgCO3: TS: SS) in each mixture are (0.224 part: 0.055 part
and 0.721 parts). Next, after further testing of the formula is then obtained properties of
the capsule shell prototype, namely: thickness (0.35 mm), solubility (66.64%), and
water vapor transmission rate (WVTR) (0.67 g.H2O.m-2
h
-1
). The data obtained that the
type of SS filler is the most dominant factor influencing in increasing the thickness and
solubility properties of the capsule shell, while the filler TS is the most dominant
increase in the nature of WVTR. The results of the study concluded that the application
of the SLD optimization method could be applied in the preparation of hard capsule
formulations made from goatskin gelatin with better properties